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KMID : 0385219910010020155
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Korean Journal of Gerontology
1991 Volume.1 No. 2 p.155 ~ p.161
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Age-relatd Changes in Body Composition, Serum Lipid Concentration and Humoral Immunity in Rats
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Won Hye-Suk
Kim Hwa-Young
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Abstract
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This study was designed to investigate age-related in body composition and humoral immunity. Male Sprague-Dawley rats were fed stock diet ad libitum and 12 rats were sacrified at 1, 4, 6, 12, 15 mos. of age. Body weight increased sharply from 1 to 4 mos. and increased steadily thereafter. The weights of liver, epididymal fat pads, and kidney increased in similar pattern as body weight, but their relative ratio to body weight decreased with age. The ratio of epididymal fat pads to body weight increased with age. At 4 and 15 mos. of age, the body content of fat, expressed as percentage of body weight, was higher and water content (percentage of body weight) was lower compared with the value of 1 mon. However there was no significant change in protein content (percentage of body weight) with age. Total lipid and triglycerides concentrations of serum and liver were higher at the ages of 4, 6, 12, 15 mos. than 1 mon., but there was no change in total cholesterol concentrations. Brain lipid and cholesterol concentrations increased with steadily, and were higher at 12 and 15 mos. of age. Femur weight and ash content increased with age but Ca concentrations decreased slowly after 4 mos. of age. Water percentage of femur decreased and ash percentage increased. The number of spleen Plaque-forming cells after immunized with sheep red blood cells decreased with age after 4 mos.
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KEYWORD
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aging in rats, organ weight, body composition, lipid content, humoral immunity
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